I would do The Ginger Man on Morningside in West Univ. Place.
Major medical center hangout, site of many a Rice U. pub crawl.
These people are serious about *beer*. There are at least 30 on tap at any given time and a couple of hundred in their Beer Menu (yes they have one.)
Very rustic kind of feel--no one will notice if you spill anything, but it doesn't stink and there are outdoor patios, etc, etc, etc.
Most of all it's unpretentious and very "come as you are".
Adrienne
(who has tipped a few wet ones over the years at the G-Man)